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Volume 24 , Issue 6
November/December 2004
Pages 579–587

Measuring the Efficacy of rhBMP-2 to Regenerate Bone: A Radiographic Study Using a Commercially Available Software Program

Jorge Bianchi, MMSc/Joseph P. Fiorellini, DMD, DMSc/T. Howard Howell, DDS/Julio Sekler, Dr Odont, MMSc, DMD/Hugh Curtin, MD/Marc L. Nevins, DDS, MMSc/Bernard Friedland, BChD, MSc, JD

PMID: 15626320
DOI: 10.11607/prd.00.0608

This radiographic study evaluated the efficacy of different concentrations of rhBMP-2 to regenerate bone in alveolar defects in the anterior maxilla. The study was performed using reasonably standardized CT examinations and the Simplant program. The radiographic measurements were further refined by careful standardization of the measured regions of interest. There was a statistically significant difference in bone formation between subjects treated with a concentration of 1.5 mg/mL rhBMP-2 compared with each of the other groups. There was no statistically significant difference in bone volume between any of the other groups. None of the groups showed a loss in bone volume. (Int J Periodontics Restorative Dent 2004;24:579–587.)

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